CannabisJuicyFieldsDigestive Diseases: Have You Already Tried Cannabis?

May 24, 2022by JuicyFields0

Many studies have assessed the effect of cannabis on experimental models of colitis, one the digestive diseases with the highest prevalence rates in the world. Some authors suggest the observed effects could be mediated by stimulating the CB2 receptor in immune cells. The human body has endocannabinoid receptors CB1 and CB2 in the gut and stomach. The studies show that administering patients with cannabis improves their motility, appetite, absorption, and gastrointestinal health, either because of the effects of THC, CBD, or both, including terpenes. There are more ways for your stomach to receive these benefits other than consuming cannabis orally through food, capsules, or drinks; you can also vape, smoke, or administer cannabis sublingually—especially since these consumption methods work faster.

Cannabis and Pharmaceutical Drugs for Digestive Diseases

There are other diseases affecting the digestive system that can be managed with the use of medical cannabis as well, and this treatment is also preferred because of the lower occurrence of side effects. Many patients using pharmaceutical drugs to control symptoms of digestive diseases report a pattern of irritation of the gastric mucosa that leads to gastritis, a higher intolerance to some kinds of food, and even drug resistance. Gastrointestinal homeostasis is related to the number of substances with which the digestive system interacts.

Although the use of cannabinoids has been around for several years, discoveries about their mechanism of action and therapeutic units are quite recent, and the same happens with disruptions in the endocannabinoid system, arising in several diseases and conditions with symptoms such as pain, inflammation, and the occurrence of autoimmune diseases and several specific organ disorders. “Inflammatory bowel disease” (IBD) is a term for two idiopathic chronic diseases whose origin is unknown, in which a disruption of the immune system plays an important role.

Alternative Therapies for Non-Remitted Patients

Alternative treatments must be developed for these patients, because only a small portion of them manage to send the disease into remission. A review of the latest evidence on the use of cannabis for ulcerative colitis (UC) and Chron’s disease (CD) suggests that the two main compounds of cannabis, cannabidiol (CBD) and tetrahydrocannabinol (THC), have been extensively examined and they have proved to bring about anti-inflammatory and antinociceptive benefits. The use of these components to treat UC and CD symptoms has been broadly described, but still, additional high-quality research is needed to keep on measuring the safety and efficacy of cannabis treatments in IDB patients.

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